【Clinical study】

1.  A Safety and Efficacy Evaluation of Hemoglobin-Based Oxygen Carrier HBOC-201 in a Randomized, Multicenter Red Blood Cell Controlled Trial in Noncardiac Surgery Patients.pdf

2. A synthetic haemoglobin-based oxygen carrier and the reversal.pdf

3. Bovine hemoglobin (glutamer-250, Hemopure)-specific.pdf

4. Cardioprotection before revascularization.pdf

5. Experience with the use of Hemopure in the care of a massively burned adult.pdf

6. Hemopure A Potential Option for Anemia in Jehovah’s Witnesses.pdf

7. Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery Results of a randomized, double-blind trial.pdf

8. Proof-of-concept trial to evaluate haemoglobin based oxygen therapeutics in elective percutaneous coronary revascularisation. Rationale, protocol design and haemodynamic results.pdf

9. South Africa clinical experience with Hemopure.pdf

10. The reduction of the allogenic transfusion requirement in aortic surgery with a Hemoglobin- based solution.pdf

11. The Successful Use of Hemoglobin-Based Oxygen Carrier as a Primary Blood Substitute During Abdominal Aneurysm Repair with Large Blood Loss.pdf

12. The Use of Bovine Hemoglobin Glutamer-250 (Hemopure®) in Surgical Patients Results of a Multicenter, Randomized, Single-Blinded Trial.pdf

13. US Navy experience with research on, and development of, hemoglobin-based oxygen carriers.pdf

14. Use of the blood substitute HBOC-201 in critically ill patients during sickle crisis a three-case series.pdf

【Pharmacology and Toxicology】

1. A comparison of the hemoglobin based oxygen carrier HBOC-201 to other low volume resuscitation fluids in a model of controlled hemorrhagic shock.pdf

2. A hemoglobin-based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in a moderate severity hemorrhagic shock swine model with delayed evacuation.pdf

3. A novel hemoglobin-based blood substitute protects against myocardial reperfusion injury.pdf

4. A polymerized bovine hemoglobin oxygen carrier preserves regional myocardial function and reduces infarct size after acute myocardial ischemia.pdf

5. Acute and long-term effects of modified hemoglobin (HBOC-201) in a rat model of hypertension and chronic kidney disease.pdf

6. BOVINE HEMOGLOBIN-BASED OXYGEN-CARRYING SOLUTION (HBOC-201) IMPROVES FLAP SURVIVAL IN A RAT MODEL OF EPIGASTRIC FLAP FAILURE.pdf

7. Bovine polymerized hemoglobin (hemoglobin-based oxygen carrier-201) resuscitation in three swine models of hemorrhagic shock with militarily relevant delayed evacuation—Effects on histopathology and organ function.pdf

8. BOVINE POLYMERIZED HEMOGLOBIN VERSUS HEXTEND RESUSCITATION IN A SWINE MODEL OF SEVERE CONTROLLED HEMORRHAGIC SHOCK WITH DELAY TO DEFINITIVE CARE.pdf

9. Coagulation patterns following haemoglobin-based oxygen carrier resuscitation in severe uncontrolled haemorrhagic shock in swine.pdf

10. EFFECTS OF BOVINE POLYMERIZED HEMOGLOBIN ON COAGULATION IN CONTROLLED HEMORRHAGIC SHOCK IN SWINE.pdf

11. Enhanced central organ oxygenation after application of bovine cell-free hemoglobin HBOC-201.pdf

12. Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled hemorrhage with prolonged delayed definitive care.pdf

13. Hemoglobin-based oxygen carrier HBOC-201 provides higher and faster increase in oxygen tension in skeletal muscle of anemic dogs than do stored red blood cells.pdf

14. IMMUNE EFFECTS OF RESUSCITATION WITH HBOC-201, A HEMOGLOBIN-BASED OXYGEN CARRIER, IN SWINE WITH MODERATELY SEVERE HEMORRHAGIC SHOCK FROM CONTROLLED HEMORRHAGE.pdf

15. Influence of the Hemoglobin Solution HBOC-201 on Tissue Oxygenation in the Rat R1H-Tumor.pdf

16. Low-Volume Resuscitation with a Polymerized Bovine Hemoglobin-Based Oxygen-Carrying Solution(HBOC-201).pdf

17. Prehospital HBOC-201 After Traumatic Brain Injury and Hemorrhagic Shock in Swine.pdf

18. Prehospital hemoglobin-based oxygen carrier resuscitation attenuates postinjury acute lung injury.pdf

19. Prolonged Low-Volume Resuscitation with HBOC-201 in a Large-Animal Survival Model of Controlled Hemorrhage.pdf

20. Resuscitation following severe, controlled hemorrhage associated with a 24 h delay to surgical intervention in swine using a hemoglobin based oxygen carrier as an oxygen bridge to definitive care.pdf

21. Resuscitation From Hemorrhagic Shock Comparing Standard Hemoglobin-Based Oxygen Carrier (HBOC)-201 Versus 7.5% Hypertonic HBOC-201.pdf

22. RESUSCITATION FROM HEMORRHAGIC SHOCK WITH HBOC-201 IN THE SETTING OF TRAUMATIC BRAIN INJURY.pdf

23. The Effect of Hemopure® on Coagulation in Clinically Relevant Concentrations.pdf

24. The use of a hemoglobin-based oxygen-carrying solution (HBOC-201) for extracorporeal membrane oxygenation in a porcine model with acute respiratory distress syndrome.pdf

25. Vasoactivity of Bovine Polymerized Hemoglobin (HBOC-201) in Swine With Traumatic Hemorrhagic Shock With and Without Brain Injury.pdf

【Clinical Study】

1. Inadequacy of low-volume resuscitation with hemoglobin-based oxygen carrier hemoglobin glutamer-200 (bovine) in canine hypovolemia.pdf

【Pharmacology and Toxicology】

1. Effects of haemoglobin-based oxygen carrier Hemoglobin glutamer-200(bovine) on intestinal perfusion and oxygenation in a canine hypovolaemia model.pdf

2. Effects of isovolemic resuscitation with hemoglobin based oxygen carrier Hemoglobin glutamer 200 (bovine) on systemic and mesenteric perfusion and oxygenation in a canine.pdf

3. Effects of low volume hemoglobin glutamer 200 versus normal saline.pdf

4. Improvement of Impaired Microcirculation and Tissue Oxygenation by Hemodilution with Hydroxyethyl Starch plus Cell-Free Hemoglobin in Acute Porcine Pancreatitis.pdf

5. Microcirculatory Function and Tissue Damage Is Improved After Therapeutic Injection of Bovine Hemoglobin in Severe Acute Rodent Pancreatitis.pdf

6. Resuscitation With a Hemoglobin-Based Oxygen Carrier After Traumatic Brain Injury.pdf

7. Systemic function, oxygenation and microvascular correlation during treatment of hemorrhagic shock with blood substitutes.pdf